Journal of the Chinese Chemical Society

Utility of β??(4??Chlorobenzoyl) acrylic Acid in Heterocyclic Synthesis

AMF Eissa

Index: Eissa Journal of the Chinese Chemical Society, 2005 , vol. 52, # 6 p. 1205 - 1214

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Citation Number: 1

Abstract

Abstract β-(4-Chlorobenzoyl) acrylic acid (1) proved to be a convenient precursor for the synthesis of a variety of heterocyclic systems through the reaction with compounds containing active methylene groups under Michael reaction conditions. Also, the reactivity of Michael adduct towards nitrogen nucleophiles was investigated to afford diazepine, indazole, isoxazole and quinazoline derivatives. Some of the synthesized compounds ...

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