Practical resolution of 1-phenyl-2-(4-methylphenyl) ethylamine using a single resolving agent controlled by the dielectric constant of the solvent

…, R Sakurai, H Nohira, R Tanaka, N Hirayama

Index: Sakai, Kenichi; Sakurai, Rumiko; Nohira, Hiroyuki; Tanaka, Rumiko; Hirayama, Noriaki Tetrahedron Asymmetry, 2004 , vol. 15, # 22 p. 3495 - 3500

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Citation Number: 34

Abstract

A practical resolution of 1-phenyl-2-(4-methylphenyl) ethylamine 1 for obtaining (R)-and (S)- enantiomers by a dielectrically controlled resolution (DCR) method using a single resolving agent,(S)-mandelic acid 2, has been studied. The configuration of the excess enantiomer 1 in the less-soluble diastereomeric salt was found to vary depending on the solvent controlled by adjusting the solvent dielectric constant ε and the water content of the ...

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