Medicinal Chemistry Research

Synthesis, cytotoxicity, and molecular properties prediction of novel 1, 3-diarylpyrazole derivatives

SN Baytas, N Inceler, A Yılmaz

Index: Baytas, Sultan Nacak; Inceler, Nazan; Yilmaz, Akin Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4893 - 4908

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Citation Number: 3

Abstract

Abstract A novel combinatorial library of ester and amide derivatives of 1, 3-diarylpyrazoles was designed and synthesized. Anticancer activities of these compounds were assessed against MCF7, MDA-MB-231, HeLa, Raji, and HL60 human cancer cells by MTT assay. Out of these, compounds 4c and 5f were found as the most promising anticancer agents with IC 50 values of 8.12 and 9.63 μM in Raji cells, respectively. All compounds exhibited suitable ...