Diheteropeptin, a New Substance with TGF-. BETA.-like Activity, Produced by a Fungus, Diheterospora chlamydosporia. I. Production, Isolation and Biological …

…, K Nagai, KI Suzuki, Y Hayakawa, H Seto

Index: Masuoka; Shin-ya; Furihata; Matsumoto; Takebayashi; Nagai; Suzuki; Hayakawa; Seto Journal of Antibiotics, 2000 , vol. 53, # 8 p. 793 - 798

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Citation Number: 19

Abstract

A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-β-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in MvlLu cells with an IC 50 value of 20.3 μM and inhibited histone deacetylase.

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