Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors

…, BP Roques, MC Fournie-Zaluski

Index: Coric, Pascale; Turcaud, Serge; Meudal, Herve; Roques, Bernard Pierre; Fournie-Zaluski, Marie-Claude Journal of Medicinal Chemistry, 1996 , vol. 39, # 6 p. 1210 - 1219

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Citation Number: 21

Abstract

An interesting approach for the treatment of congestive heart failure and chronic hypertension could be to avoid the formation of angiotensin II by inhibiting angiotensin converting enzyme (ACE) and to protect atrial natriuretic factor by blocking neutral endopeptidase 24.11 (NEP). This is supported by recent results obtained with potent dual inhibitors of the two zinc metallopeptidases, such as RB 105, HSCH2CH (CH3) ...

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Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors

[Journal of Medicinal Chemistry, , vol. 39, # 6 p. 1210 - 1219]

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Optimal recognition of neutral endopeptidase and angiotensin-converting enzyme active sites by mercaptoacyldipeptides as a means to design potent dual inhibitors

Abstract

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