Antimalarial amino alcohols II: Anthraceneaminoethanols and anthraceneaminopropanols (1??and 9??substituted)

…, MJ Moats, EP Lira, CW Huffman

Index: Traxler; Moats; Lira; Huffman Journal of Pharmaceutical Sciences, 1975 , vol. 64, # 12 p. 1943 - 1949

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Citation Number: 4

Abstract

Abstract The syntheses of seven anthracene amino alcohols with one, two, or three additional substituents are described. These compounds include three 1-aminoethanols, two 9-aminoethanols, and two 9-aminopropanols, prepared from substituted anthraquinones or from 10-chloro-9-anthraldehydes. The antimalarial activity of these compounds, as well as tentative structure-activity relationships, is discussed in the light of previously published ...