Synthesis

Mild zinc-promoted horner-wadsworth-emmons reactions of diprotic phosphonate reagents

DJ Schauer, P Helquist

Index: Schauer, Douglas J.; Helquist, Paul Synthesis, 2006 , # 21 p. 3654 - 3660

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Citation Number: 19

Abstract

Abstract We report the development of a mild protocol for the Horner-Wadsworth-Emmons reaction of diprotic phosphonates that makes use of a zinc triflate promoter in the presence of mild tertiary amine bases to produce α, β-unsaturated carboxylic acids and amides.

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