Structure–Activity Relationships of Glucosamine??Derived Glycerolipids: the Role of the Anomeric Linkage, the Cationic Charge and the Glycero Moiety on the …

Y Xu, M Ogunsina, P Samadder, G Arthur…

Index: Xu, Yaozu; Ogunsina, Makanjuola; Samadder, Pranati; Arthur, Gilbert; Schweizer, Frank ChemMedChem, 2013 , vol. 8, # 3 p. 511 - 520

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Citation Number: 6

Abstract

Abstract The potent antitumor activity of 1-O-hexadecyl-2-O-methyl-3-O-(2′-amino-2′- deoxy-β-D-glucopyranosyl)-sn-glycerol (1) was previously shown to arise through an apoptosis-independent pathway. Here, a systematic structure–activity study in which the effects of the anomeric linkage, the cationic charge and the glycero moiety on the antitumor activity is described. Eight analogues of 1 were synthesized, and their antitumor activity ...