The Journal of organic chemistry

Synthesis of ring-fused oxazolo-and pyrazoloisoquinolinones by a one-pot Pd-catalyzed carboxamidation and Aldol-type condensation cascade process

G Chouhan, H Alper

Index: Chouhan, Gagan; Alper, Howard Journal of Organic Chemistry, 2009 , vol. 74, # 16 p. 6181 - 6189

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Citation Number: 23

Abstract

A three-component cascade process is described for the synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones by a one-pot carboxamidation/aldol-type condensation reaction. The cascade process involves Pd-catalyzed carboxamidation of an aryl halide/active methylene compound with oxazolidinone or pyrazolidinone, and subsequent intramolecular base-catalyzed cyclization/dehydration through an aldol-type condensation ...