Journal of medicinal chemistry

Antimalarials. 4. Trichloronaphthalene amino alcohols

DA Shamblee, JS Gillespie Jr

Index: Shamblee,D.A.; Gillespie,J.S. Journal of Medicinal Chemistry, 1979 , vol. 22, p. 86 - 89

Full Text: HTML

Citation Number: 9

Abstract

An improved procedure for the synthesis of naphthalene amino alcohols is described. Four new compounds were prepared and tested by Rane Laboratories for activitj. i's. P/n., n? odiiini hwghei in mice.. Ill compounds were active. the most active being l-[~ i-14- chlorophenylI-5.7-d~ chl~~ rc~-l-naphthyl]-~~-~ d~-~~-butylarn~ no~ pr~ ipan1~ l hydrochloride i 16b). Structure-activity relationships betwren the naphthalene and ...