Base-catalyzed and cholinesterase-catalyzed hydrolysis of acetylcholine and optically active analogs

KB Schowen, EE Smissman…

Index: Schowen,K.B. et al. Journal of Medicinal Chemistry, 1975 , vol. 18, p. 292 - 300

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Citation Number: 17

Abstract

The base. and cholinesterase-caralyzed hydrolyses of the following optically active analogs of acetylcholine were studied:? da)-trimethvlamrnonium-2 (ai-acetoxy-trans-decalin iodide. threo-and t~~ thro-ci, d-dimethylacetylcholine iodide, u-methylacetylcholine. and 3- methylacetylcholine. Evidence that the optimum dihedral-5-CC-0 angle in the transition state for acetylcholinesterase hydrolysis of acetylcholine analogs is positive and anticlinal is ...