S-adenosylcoenzyme M and (±) S-methyl adenosylcoenzyme M. Preparation and role in methane biosynthesis

WR Cullen, D Dolphin, D Hoffman…

Index: Cullen, William R.; Dolphin, David; Hoffman, Dale; Trip, Everard Canadian Journal of Chemistry, 1984 , vol. 62, p. 2136 - 2139

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Citation Number: 2

Abstract

5'-S-(2-Sulphoethyl)-5'-deoxy-5'-thioadenosine (S-adenosylcoenzyme M), 5, was prepared from adenosine by reacting its 2', 3'-isopropylidine tosylate with the disodium salt of coenzyme M (NaSCH2CH2SO3Na) followed by removal of the protecting group. Methylation of 5 to give methylsulphonium (±) S-adenosylcoenzyme M, 6, was achieved with methyl iodide in acetic acid. Neither 5 nor 6 stimulated methane production from cell free ...