RESEARCHES ON HYDANTOINS. L. 1 THE SYNTHESIS OF HYDANTOINS POSSESSING THE PROPERTIES OF HYPNOTICS

RM Herbst, TB Johnson

Index: Herbst; Johnson Journal of the American Chemical Society, 1932 , vol. 54, p. 2463,2467

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Citation Number: 10

Abstract

That the hydantoin nucleus exhibits hypnotic properties has been known for several years. This pharmacological behavior is most pronounced in the drug “nirvunol” (phenylethylhydantoin) I, which is the hydantoin analog of the pyrimidine “luminal” or phenylethylbarbituric acid 11. The latter cyclic ureide and several of its representatives have been used effectively as sedatives and hypnotics in simple insomnia, hysteria, neu- rasthenia, thyroid disease, chorea, ...

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