(R, R, R)-2, 5-Diaminocylohexanecarboxylic Acid, a Building Block for Water-Soluble, Helix-Forming β-Peptides

…, PR LePlae, TL Raguse, SH Gellman

Index: Appella, Daniel H.; LePlae, Paul R.; Raguse, Tami L.; Gellman, Samuel H. Journal of Organic Chemistry, 2000 , vol. 65, # 15 p. 4766 - 4769

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Citation Number: 32

Abstract

Unnatural oligomers with discrete and predictable folding propensities (“foldamers”) are subjects of considerable current interest. 1 Attention in our laboratory and several others has focused on oligomers of β-amino acids (“β-peptides”). 1-3 We have shown, for example, that oligomers of trans-2-aminocyclohexanecarboxylic acid (ACHC) adopt a helical conformation that has approximately three residues per turn and contains a network of 14-membered ...