Amino acids derived benzoxazepines: Design, synthesis and antitumor activity

…, B Chakravarti, S Mondal, R Konwar, AK Trivedi…

Index: Dwivedi, Shailendra Kumar Dhar; Samanta, Krishnananda; Yadav, Manisha; Jana, Amit Kumar; Singh, Abhishek Kumar; Chakravarti, Bandana; Mondal, Sankalan; Konwar, Rituraj; Trivedi, Arun Kumar; Chattopadhyay, Naibedya; Sanyal, Sabyasachi; Panda, Gautam Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6816 - 6821

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Citation Number: 10

Abstract

Abstract Two series of new benzoxazepines substituted with different alkyl amino ethyl chains were synthesized comprising synthetic steps of inter and intramolecular Mitsunobu reaction, lithium aluminium hydride (LAH) reduction, debenzylation, bimolecular nucleophilic substitution (SN 2) reaction. The present study investigates the effect of a tyrosine-based benzoxazepine derivative in human breast cancer cells MCF-7 and MDA- ...