Cytokinin-derived cyclin-dependent kinase inhibitors: synthesis and cdc2 inhibitory activity of olomoucine and related compounds

L Havlicek, J Hanuš, J Veselý, S Leclerc…

Index: Havlicek, Libor; Hanus, Jan; Vesely, Jaroslav; Leclerc, Sophie; Meijer, Laurent; Shaw, Gordon; Strnad, Miroslav Journal of Medicinal Chemistry, 1997 , vol. 40, # 4 p. 408 - 412

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Citation Number: 246

Abstract

Cyclin-dependent kinases (cdk) have recently raised considerable interest in view of their essential role in the regulation of the cell division cycle. The structure-activity relationships of cdk inhibition showed that the 1, 3, and 7 positions of the purine ring must remain free, probably for a direct interaction, in which it behaves as a hydrogen bond acceptor. Olomoucine (6-(benzylamino)-2-[(2-hydroxyethyl) amino]-9-methylpurine, OC), roscovitine ...