Maximizing lipophilic efficiency: the use of Free-Wilson analysis in the design of inhibitors of acetyl-CoA carboxylase

KD Freeman-Cook, P Amor, S Bader…

Index: Journal of Medicinal Chemistry, , vol. 55, # 2 p. 935 - 942

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Citation Number: 19

Abstract

... Journal of Medicinal ... Key findings include the discovery of an initial lead that was modestly potent and subsequent medicinal chemistry optimization with a ... in m-CoA production, acetyl-CoA carboxylase (ACC) is a target of significant interest within the pharmaceutical industry.(6 ...