Pyrazole-tethered arylphosphine ligands for Suzuki reactions of aryl chlorides: how important is chelation?

A Mukherjee, A Sarkar

Index: Mukherjee, Anuradha; Sarkar, Amitabha Tetrahedron Letters, 2004 , vol. 45, # 52 p. 9525 - 9528

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Citation Number: 30

Abstract

Pyrazole-derived bidentate ligands (P, N-donor) with bulky substituents at the 3-position of the pyrazole, 1b–d, were used with Pd2 (dba) 3 to carry out efficient Suzuki coupling reactions with both aryl bromides and chlorides. Enhanced catalytic activity on account of steric crowding in the metal complex suggested participation of a chelated structure in the intermediate catalytic steps.