Electrophilic cyclization of o-acetoxy-and o-benzyloxyalkynylpyridines: An easy entry into 2, 3-disubstituted furopyridines

…, S Cacchi, S Di Giuseppe, G Fabrizi, F Marinelli

Index: Arcadi, Antonio; Cacchi, Sandro; Di Giuseppe, Sabrina; Fabrizi, Giancarlo; Marinelli, Fabio Organic Letters, 2002 , vol. 4, # 14 p. 2409 - 2412

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Citation Number: 137

Abstract

2, 3-Disubstituted furo [3, 2-b] pyridines, 2, 3-disubstituted furo [2, 3-b] pyridines, and 2, 3- disubstituted furo [2, 3-c] pyridines are readily prepared under mild conditions via the palladium-catalyzed cross-coupling of 1-alkynes with o-iodoacetoxy-or o- iodobenzyloxypyridines, followed by electrophilic cyclization by I2 or by PdCl2 under a balloon of carbon monoxide.

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