Modular Phosphine??Aminophosphine Ligands Based on Chiral 1, 2, 3, 4??Tetrahydro??1??naphthylamine Backbone: A New Class of Practical Ligands for …

…, XP Hu, JD Huang, DY Wang, J Deng…

Index: Qiu, Min; Hu, Xiang-Ping; Huang, Jia-Di; Wang, Dao-Yong; Deng, Jun; Yu, Sai-Bo; Duan, Zheng-Chao; Zheng, Zhuo Advanced Synthesis and Catalysis, 2008 , vol. 350, # 17 p. 2683 - 2689

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Citation Number: 19

Abstract

Abstract A series of new chiral phosphine-aminophosphine ligands [(R)-HW-Phos] has been prepared from (R)-1, 2, 3, 4-tetrahydro-1-naphthylamine through a two-step procedure, and successfully applied in the rhodium-catalyzed asymmetric hydrogenation of various functionalized olefins such as α-enol ester phosphonates, α-enamido phosphonates,(Z)-β- (acylamino) acrylates and so on. Excellent enantioselectivities have been achieved in the ...