Pteridines. Part LXXXV. Chemical synthesis of deoxysepiapterin and 6??acylpteridines by acyl radical substitution reactions
R Baur, T Sugimoto, W Pfleiderer
Index: Baur, Ralph; Sugimoto, Takashi; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1988 , vol. 71, p. 531 - 543
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Citation Number: 21
Abstract
Abstract A new synthesis of deoxysepiapterin (2), one of the two yellow eye pigments of the Drosophila mutant sepia, is described. The synthetic approach makes use of a homolytic nucleophilic acylation of 7-(alkylthio) pteridine derivatives (11, 13, 15, 18, 20) leading to the corresponding 6-acyl derivatives (21–27). Desulfurizations have been achieved for the first time in the pteridine series using Raney-Co, Raney-Cu, or Cu [BOND] Al alloy in alkaline ...
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