Basic antiinflammatory compounds. N, N', N''-Trisubstituted guanidines

…, I Ahnfelt-Rønne, E Arrigoni-Martelli

Index: Rachlin, Schneur; Bramm, E.; Ahnfelt-Ronne, I.; Arrigoni-Martelli, E. Journal of Medicinal Chemistry, 1980 , vol. 23, # 1 p. 13 - 20

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Citation Number: 21

Abstract

A variety of basic N, N', N”-trisubstituted guanidines was prepared and tested for antiinflammatory activity. Compounds with a thiazolylguanidine moiety linked to the 4 position of the 2-methylquinoline ring exhibited fairly high antiinflammatory activity. Optimal activity was associated with the presence of N-cycloalkyl substituents on