Design and synthesis of macro-heterocycles structurally related to tirofiban

M Ramaseshan, M Robitaille, JW Ellingboe, YL Dory…

Index: Ramaseshan, Mahesh; Robitaille, Martin; Ellingboe, John W.; Dory, Yves L.; Deslongchamps, Pierre Tetrahedron Letters, 2000 , vol. 41, # 24 p. 4737 - 4742

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Citation Number: 16

Abstract

Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18-or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence.

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