Carbohydrate research

Synthesis of mucin O-glycan core structures as their p-nitro-and p-aminophenyl glycosides

M Hollinger, F Abraha, S Oscarson

Index: Hollinger, Martin; Abraha, Fana; Oscarson, Stefan Carbohydrate Research, 2011 , vol. 346, # 12 p. 1454 - 1466

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Citation Number: 4

Abstract

Abstract For the investigation of glycosidases, and for the construction of glycan arrays the p- nitrophenyl-and p-aminophenyl glycosides of mucin O-glycan core structures 1–7 and the 2, 6-ST-antigen have been chemically synthesized using d-galactose as a precursor for GalNAc residues. GlcNAc residues have partly been introduced using a 4, 6-di-O-benzoyl-2, 3-N, O-oxazolidinone-protected donor, which allowed deprotection of the formed di-and tri ...

Synthesis of mucin O-glycan core structures as their p-nitro-and p-aminophenyl glycosides