A simple route for synthesis of 4-phospho-d-erythronate

Y Novikov, SD Copley, BE Eaton

Index: Novikov, Yehor; Copley, Shelley D.; Eaton, Bruce E. Tetrahedron Letters, 2011 , vol. 52, # 16 p. 1913 - 1915

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Abstract

4-Phospho-d-erythronate is an intermediate in the synthesis of pyridoxal 5′-phosphate in some bacteria and an inhibitor of ribose 5-phosphate isomerase. Previous synthetic schemes for the preparation of 4-phospho-d-erythronate required expensive precursors and typically gave low yields. We report a straightforward synthesis of 4-phospho-d-erythronate from the inexpensive precursor d-erythronolactone in five steps with a preparatively useful ...