The Effects of Alkyl Substitution in Drugs--I. Substituted Dimethylaminoethyl Benzhydryl Ethers

AF Harms, WT Nauta

Index: Harms,A.F.; Nauta,W.T. J. Med. Chem., 1960 , vol. 2, p. 57 - 77

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Citation Number: 51

Abstract

The relation between chemical structure and biological activity is still the central problem of drug research. Formerly, the solution of this problem was sought in the classification of various atoms and atom groups in a system of therapogenic groups, each making a specific contribution to the therapeutic effect of the drug in the molecule in which these groups were present. This view distracted attention from the fact that compounds which differ ...