Organic letters

A Rhodium IBiox [(−)-menthyl] Complex as a Highly Selective Catalyst for the Asymmetric Hydroarylation of Azabicyles: An Alternative Route to Epibatidine

J Bexrud, M Lautens

Index: Bexrud, Jason; Lautens, Mark Organic Letters, 2010 , vol. 12, # 14 p. 3160 - 3163

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Citation Number: 46

Abstract

The synthesis and characterization of a new chiral rhodium N-heterocyclic carbene complex, Rh (IBiox [(−)-menthyl](CO) 2Cl, is reported. In addition, the very high enantioselectivity exhibited by this complex, as a catalyst for the asymmetric hydroarylation of azabicycles, is demonstrated and applied to the synthesis of epibatidine.