Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5′-monophosphate decarboxylase

…, AM Bello, E Poduch, Y Liu, CJ Paige…

Index: Bello, Angelica M.; Konforte, Danijela; Poduch, Ewa; Furlonger, Caren; Wei, Lianhu; Liu, Yan; Lewis, Melissa; Pai, Emil F.; Paige, Christopher J.; Kotra, Lakshmi P. Journal of Medicinal Chemistry, 2009 , vol. 52, # 6 p. 1648 - 1658

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Citation Number: 6

Abstract

Fluorinated nucleosides and nucleotides are of considerable interest to medicinal chemists because of their antiviral, anticancer, and other biological activities. However, their direct interactions at target binding sites are not well understood. A new class of 2′-deoxy-2′- fluoro-C6-substituted uridine and UMP derivatives were synthesized and evaluated as inhibitors of orotidine 5′-monophosphate decarboxylase (ODCase or OMPDCase). ...

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