ACS combinatorial science

Synthesis and library construction of privileged tetra-substituted Δ5-2-oxopiperazine as β-turn structure mimetics

J Kim, WS Lee, J Koo, J Lee…

Index: Kim, Jonghoon; Lee, Won Seok; Koo, Jaeyoung; Lee, Jeongae; Park, Seung Bum ACS Combinatorial Science, 2014 , vol. 16, # 1 p. 24 - 32

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Citation Number: 8

Abstract

In this study, we developed an efficient and practical procedure for the synthesis of tetra- substituted Δ5-2-oxopiperazine that mimics the bioactive β-turn structural motif of proteins. This synthetic route is robust and modular enough to accommodate four different substituents to obtain a high level of molecular diversity without any deterioration in stereochemical enrichment of the natural and unnatural amino acids. Through the in silico ...