Total synthesis of isorobustin

DHR Barton, DMX Donnelly, JP Finet, PJ Guiry

Index: Barton, Derek H. R.; Donnelly, Dervilla M. X.; Finet, Jean-Pierre; Guiry, Patrick J. Tetrahedron Letters, 1990 , vol. 31, # 51 p. 7449 - 7452

Full Text: HTML

Citation Number: 31

Abstract

Abstract: The synthesis of isorobustin L in four steps from S-methoxyresorcinol proceeds in an overall yield of 34%. The key step involves the arylation of a I-hydroxy-IH-lbensopyran-2- one 4 by 3.4~ met~ lenedio~ pknylleaa'triacetate 2 in a chemoselective and regioselective manner.