Synthetic study on the unique dimeric arylpiperazine: access to the minor contaminant of aripiprazole

…, K Shinhama, T Nishi, J Minamikawa

Index: Torisawa, Yasuhiro; Shinhama, Koichi; Nishi, Takao; Minamikawa, Jun-ichi Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 1 p. 65 - 68

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Citation Number: 3

Abstract

The dimeric derivative of Aripiprazole was synthesized via the two notable synthetic technologies as a key step:(1) efficient aldehyde bis-arylation by Bi (OTf) 3 and (2) facile Wynberg amination at room temperature. The synthesis has established the structural identity with the minor contaminant sometimes present in Aripiprazole.