Synthesis and structure-affinity relationships of novel N-(1-ethyl-4-methylhexahydro-1, 4-diazepin-6-yl) pyridine-3-carboxamides with potent serotonin 5-HT3 and …

Y Hirokawa, I Fujiwara, K Suzuki…

Index: Horikawa; Hirokawa; Kato Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 12 p. 1621 - 1627

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Citation Number: 30

Abstract

A structurally original series of N-(1-ethyl-4-methylhexahydro-1, 4-diazepin-6-yl) pyridine-3- carboxamides derived from the corresponding benzamide 5 were prepared and evaluated for their binding affinity for the dopamine D2 and serotonin 5-HT3 receptors using rat

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