Guanosine analogs. Synthesis of nucleosides of certain 3-substituted 6-aminopyrazolo [3, 4-d] pyrimidin-4 (5H)-ones as potential immunotherapeutic agents

RJ Bontems, JD Anderson, DF Smee…

Index: Bontems, Roger J.; Anderson, Jack D.; Smee, Donald F.; Jin, Ai; Alaghamandan, Hassan A.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2174 - 2178

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Citation Number: 19

Abstract

2. R= SH syntheses of which were reported by Robins and coworker~~% over 10 years before their immunostimulatory properties were discovered. These low molecular weight nucleosides have been shown to act as intracellular mitogens in murine splenic B lymphocytes4 and appear to be relatively T-cell-independent activators of a subset of human B cells committed to the expression of IgM, IgG, or IgA i~ otypes.~ In addition, these ...