Direct C− H arylation of electron-deficient heterocycles with arylboronic acids

…, RA Rodriguez, R Gianatassio, Y Fujiwara…

Index: Seiple, Ian B.; Su, Shun; Rodriguez, Rodrigo A.; Gianatassio, Ryan; Fujiwara, Yuta; Sobel, Adam L.; Baran, Phil S. Journal of the American Chemical Society, 2010 , vol. 132, # 38 p. 13194 - 13196

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Citation Number: 246

Abstract

A direct arylation of a variety of electron-deficient heterocycles with arylboronic acids has been developed. This new reaction proceeds readily at room temperature using inexpensive reagents: catalytic silver (I) nitrate in the presence of persulfate co-oxidant. The scope with respect to heterocycle and boronic acid coupling partner is broad, and sensitive functional groups are tolerated. This method allows for rapid access to a variety of arylated ...

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