Tetrahedron

Synthesis of new substituted quinolizidines as potential inhibitors of ergosterol biosynthesis

A Godard, P Lamour, P Ribereau, G Quéguiner

Index: Godard, Alain; Lamour, Philippe; Ribereau, Pierre; Queguiner, Guy Tetrahedron, 1995 , vol. 51, # 11 p. 3247 - 3264

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Citation Number: 7

Abstract

Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol. Protonated aza-analogues of the sterol are thus potential inhibitors. The synthesis of substituted quinolizidines (3) is reported. 4- Methoxy-2, 3-dimethylpyridine (4) was metalated and reacted with substituted 3- chloropropanal to build the 1-methyl-2-quinolizidinone. The lateral chain was prepared ...