Alternative Strategies for the Fmoc Solid??Phase Synthesis of O4??Phospho??L??tyrosine??Containing Peptides

…, R Knorr, A Trzeciak, W Bannwarth

Index: Kitas, Eric A.; Knorr, Reinhard; Trzeciak, Arnold; Bannwarth, Willi Helvetica Chimica Acta, 1991 , vol. 74, # 6 p. 1314 - 1328

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Citation Number: 115

Abstract

Abstract A number of biologically relevant O 4-phospho-L-tyrosine-containing peptides have been synthesized by either the global phosphorylation of the side-chain-unprotected L- tyrosine moiety in presynthesized resin-bound peptides or alternatively by the incorporation of suitably protected O 4-phospho-L-tyrosine building blocks in the continuous-flow method of Fmoc solid-phase peptide synthesis. Different phosphate-protecting groups have been ...