Bioorganic & medicinal chemistry

Curcumin-I Knoevenagel's condensates and their Schiff's bases as anticancer agents: Synthesis, pharmacological and simulation studies

I Ali, A Haque, K Saleem, MF Hsieh

Index: Ali, Imran; Haque, Ashanul; Saleem, Kishwar; Hsieh, Ming Fa Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 13 p. 3808 - 3820

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Citation Number: 23

Abstract

Pyrazolealdehydes (4a–d), Knoevenagel's condensates (5a–d) and Schiff's bases (6a–d) of curcumin-I were synthesized, purified and characterized. Hemolysis assays, cell line activities, DNA bindings and docking studies were carried out. These compounds were lesser hemolytic than standard drug doxorubicin. Minimum cell viability (MCF-7; wild) observed was 59%(1.0 μg/mL) whereas the DNA binding constants ranged from 1.4× 103 ...

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