Bioorganic & Medicinal Chemistry Letters

Syntheses of myo-inositol-1, 2, 3, 5-and-2, 4, 5, 6-tetrakisphosphates, unusual inhibitors of myo-inositol-1, 4, 5-trisphosphate 3-kinase

SK Chung, YT Chang

Index: Chung, Sung-Kee; Chang, Young-Tae Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 21 p. 2715 - 2718

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Citation Number: 11

Abstract

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... D-myo-Inositol 1,4,5-trisphosphate [DI(1,4,5)P 3 ], a calcium mobilizing second messenger, is converted to DI(1,3,4,5)P 4 by DI(1,4,5)P 3 -3-kinase. Efficient syntheses of I(1,2,3,5)P 4 (2) and I(2,4,5,6)P 4 (3), novel 3-kinase inhibitors, are reported. ... 1,4,5-trisphosphate [d-I(1,4,5) ...

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