Synthesis of 2??(N??benzylpyrrolyl)??benzimidazoles using polyphosphoric acid prompted cyclocondensation

…, M Gangapuram, N Mateeva, T Ardley…

Index: Mochona, Bereket; Le, Laine; Gangapuram, Madhavi; Mateeva, Nelly; Ardley, Tiffany; Redda, Kinfe K. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 6 p. 1367 - 1371

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Abstract

Benzimidazole derivatives are known to possess varied biological activities. Substituted benzimidazole derivatives have been reported to possess anticancer, antiulcer, antiviral, antifungal, antimicrobial, and antiinflammatory activities [1–6]. Prostaglandins and leukotriens from oxidative metabolism of arachidonic acid play established roles in the pathophysiology of inflammatory disorders [7, 8]. Pharmacological interference with ...

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