Synthesis, brain antihypoxic activity and cell neuroprotection of 1-substituted-3, 7-dimethylxanthines

…, P Peikov, J Rodriguez-Alvarez, N Danchev…

Index: Zlatkov; Peikov; Rodriguez-Alvarez; Danchev; Nikolova; Mitkov European Journal of Medicinal Chemistry, 2000 , vol. 35, # 10 p. 941 - 948

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Citation Number: 4

Abstract

Five newly synthesised original compounds were investigated for acute toxicity, influence on hexobarbital sleeping time, effect on the locomotor activity, and brain antihypoxic activity. Two of the compounds were tested in a model of glutamate induced neurotoxicity in the brain cell culture using a cell viability test. Our studies indicate that compounds 2a–c and 4 prolonged the survival time of mice in the model of anoxic hypoxia. Only compound 3 ...