Glycosylated derivatives of benzophenone, benzhydrol and benzhydril as potential venous antithrombotic agents

…, J Millet, F Picart, S Samreth, JB Chazan

Index: Bellamy, Francois; Horton, Derek; Millet, Jean; Picart, Francois; Samreth, Soth; Chazan, Jean Bernard Journal of Medicinal Chemistry, 1993 , vol. 36, # 7 p. 898 - 903

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Citation Number: 50

Abstract

A series of glycosylated derivatives of benzophenone, benzhydrol, and benzhydril has been synthesized and evaluated for potential activity as venous antithrombotic agents. Studies on structureactivity relationships revealed that compounds having an electron-withdrawing group in the benzhydril or benzhydrol moiety, and specifically those having the~-D- xylopyranosylstructure in the sugar moiety, were good antithrombotic agents in a rat ...