Phytochemistry

Non-natural cinnamic acid derivatives as substrates of cinnamate 4-hydroxylase

H Chen, H Jiang, JA Morgan

Index: Chen, Hao; Jiang, Hanxiao; Morgan, John A. Phytochemistry, 2007 , vol. 68, # 3 p. 306 - 311

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Citation Number: 20

Abstract

Cinnamate 4-hydroxylase (C4H), a monooxygenase in the plant phenylpropanoid pathway, was assayed for its ability to hydroxylate 29 substrate analogues. Nine of the tested analogues with various aromatic side chains, including 3-coumaric acid, were metabolized by C4H. Seven products from these reactive analogues were characterized using LC/MS, 1H NMR and 13C NMR spectroscopic analysis. For example, caffeic acid was the product ...