A Simple and Efficient One??Pot Synthesis of Substituted Benzo [b] furans by Sonogashira Coupling–5??endo??dig Cyclization Catalyzed by Palladium Nanoparticles in …

D Saha, R Dey, BC Ranu

Index: Saha, Debasree; Dey, Raju; Ranu, Brindaban C. European Journal of Organic Chemistry, 2010 , # 31 p. 6067 - 6071

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Citation Number: 26

Abstract

Abstract A simple and efficient procedure for the synthesis of 2-substituted benzo [b] furan derivatives has been developed by the reaction of 2-iodophenols and arylacetylenes in water catalyzed by palladium nanoparticles generated in situ in open air. The reaction does not require any additive, ligand, or co-catalyst. The reaction occurs through Sonogashira coupling of 2-iodophenols with phenylacetylenes followed by 5-endo-dig cyclization. A ...

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