Assembly of Substituted 2??Alkylquinolines by a Sequential Palladium??Catalyzed C N and C C Bond Formation

…, S Hirakawa, Y Yamaguchi, Z Yoshida

Index: Matsubara, Yoshio; Hirakawa, Saori; Yamaguchi, Yoshihiro; Yoshida, Zen-Ichi Angewandte Chemie - International Edition, 2011 , vol. 50, # 33 p. 7670 - 7673

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Citation Number: 27

Abstract

The quinoline unit represents an important structural motif found in a variety of biologically active compounds.[1] For example, 2-methylquinoline (1a) is employed in the design of pharmaceuticals and related compounds such as antischizophrenia (eg, PF-2545920),[2] antitumor (eg, lavendamycin methyl ester),[3] and anti-HIV agents (eg, styrylquinoline),[4] as well as nociceptin receptor antagonists (eg, JTC-801).[5] Cyanine dyes derived from ...

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