Asymmetric enzymatic hydration of hydroxystyrene derivatives

C Wuensch, J Gross, G Steinkellner…

Index: Wuensch, Christiane; Gross, Johannes; Steinkellner, Georg; Gruber, Karl; Glueck, Silvia M.; Faber, Kurt Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2293 - 2297 Angew. Chem., 2013 , vol. 52, p. 2293 - 2297

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Citation Number: 22

Abstract

The stereoselective addition of water across C= C bonds transforms prochiral alkenes to nonracemic alcohols and represents a major challenge in synthetic organic chemistry. In general, alkene hydration is an equilibrium reaction slightly favoring the alcohol side in 1, 4- additions and somewhat disfavored on isolated C= C bonds.[1] Acid-catalyzed alkene hydration, which follows the rule of Markovnikov, usually proceeds with low ...

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