… of α, ω-cyanoalkynes with alkynes: a versatile chemo-and regio-selective synthesis of 2, 3-substituted 5, 6, 7, 8-tetrahydroquinolines and other cycloalka [1, 2-b] …

DJ Brien, A Naiman, KPC Vollhardt

Index: Brien, David J.; Naiman, Alaric; Vollhardt, K. Peter C. Journal of the Chemical Society, Chemical Communications, 1982 , # 2 p. 133 - 134

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Citation Number: 44

Abstract

Owing to the extensive and versatile medicinal properties of pyridine derivatives1 novel approaches to the construction of this nucleus are the subject of intensive current research efforts. We have previously shown2 that cycloalka[l,2-c]- pyridines can be synthesised from cc,w-diynes and nitriles using [CpCo(CO),] (Cp = cyclopentadienyl) as catalyst, and ... (3) + R' I [C p co KO 121 ... Typically the or,m-cyanoalkyne (1) (1 equiv.), the alkyne (2) (1.1 equiv.) and CpCo(CO), (0.2 equiv.) ...

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