Organic phenyl arsonic acid compounds with potent antileukemic activity
XP Liu, RK Narla, FM Uckun
Index: Liu, Xing-Ping; Narla, Rama Krishna; Uckun, Fatih M. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 581 - 583
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Citation Number: 24
Abstract
A series of 12 organic arsonic acid compounds has been synthesized and evaluated against human B-lineage (NALM-6) and T-lineage (MOLT-3) acute lymphoblastic leukemia (ALL) cell lines. The lead compounds 2-trichloromethyl-4-[4′-(4 ″-phenylazo) phenylarsonic acid] aminoquinazoline (compound 19, PHI-P518; IC50= 1.1±0.5 μM against NALM-6 and 2.0±0.8 μM against MOLT-3) and 2-methylthio-4-(2′-phenylarsonic acid) ...
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