Synthesis and biological evaluation of novel piperazine derivatives of flavone as potent anti-inflammatory and antimicrobial agent

…, AH Rodge, SS Birajdar, RH Tale, VM Kamble

Index: Hatnapure, Girish D.; Keche, Ashish P.; Rodge, Atish H.; Birajdar, Satish S.; Tale, Rajesh H.; Kamble, Vandana M. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 20 p. 6385 - 6390

Full Text: HTML

Citation Number: 23

Abstract

A series of novel 6-methoxy-2-(piperazin-1-yl)-4H-chromen-4-one and 5, 7-dimethoxy-2- (piperazin-1-ylmethyl)-4H-chromen-4-one derivatives of biological interest were prepared and screened for their pro-inflammatory cytokines (TNF-α and IL-6) and antimicrobial activity (antibacterial and antifungal). Among all the compound screened (5a–j and 10k–t), the compounds 5c, 5g, 5h, 10l, 10m, 10n and 10r found to have promising anti-inflammatory ...