Hydrazides and sulfonylhydrazides of the quinoline series as inhibitors of serum aminooxidase

IN Gracheva, LI Gridneva, AI Tochilkin…

Index: Gracheva, I. N.; Gridneva, L. I.; Tochilkin, A. I.; Gorkin, V. Z. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 11 p. 844 - 847 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 11 p. 1336 - 1339

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Abstract

Reduction of 8-, 4-, and 2-quinolinecarboxylic acids with nickel-aluminum alloy (Raney alloy) in 10% NaOH gave 1, 2, 3, 4-tetrahydroquinoline-8-,-4-, and-2-carboxylic acids, which were converted into their ethyl esters [12] by boiling with ethanol in the presence of sulfuric acid and hydrogen peroxide, as described in [16]. The ethyl esters, on boiling with hydrazine hydrate in absolute ethanol, were converted into 1, 2, 3, 4-tetrahydroquinoline-8-,-4-, and- ...