Identification and characterisation of small-molecule inhibitors of Rv3097c-encoded lipase (LipY) of Mycobacterium tuberculosis that selectively inhibit growth of bacilli …

…, A Kumar, VK Kashyap, L Kremer, R Srivastava…

Index: Saxena, Anil K.; Roy, Kuldeep K.; Singh, Supriya; Vishnoi; Kumar, Anil; Kashyap, Vivek Kr.; Kremer, Laurent; Srivastava, Ranjana; Srivastava, Brahm S. International Journal of Antimicrobial Agents, 2013 , vol. 42, # 1 p. 27 - 35

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Citation Number: 8

Abstract

The mycobacterial Rv3097c-encoded lipase LipY is considered as a true lipase involved in the hydrolysis of triacylglycerol stored in lipid inclusion bodies for the survival of dormant mycobacteria. To date, orlistat is the only known LipY inhibitor. In view of the important emerging role of this enzyme, a search for small-molecule inhibitors of LipY was made, leading to the identification of some new compounds (8a–8d, 8f, 8h and 8i) with potent ...